Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors.
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چکیده
منابع مشابه
Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors.
A major diagnostic marker in most rheumatoid arthritis (RA) patients is the rheumatoid factor (RF), an autoantibody that binds to the Fc region of IgG. To delineate the Ig genes and the underlying mechanism for RF production in RA patients, we applied a systematic approach to define the genetic origins of three IgG RFs derived from the synovial fluid of two RA patients. The results show that tw...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1994
ISSN: 0021-9738
DOI: 10.1172/jci117265